2012年11月22日
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
Alex J. Kuo, Jikui Song, Peggie Cheung, Satoko Ishibe-Murakami, Sayumi Yamazoe, James K. Chen, Dinshaw J. Patel & Or Gozani
Nature 484, 115-119 (05 April 2012)
The authors identify the BAH (Bromo Adjacent Homology) domain of ORC1 (Origin Recognition Complex 1) as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism.
（担当：山本(竜)）