2012年7月12日

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

Toshinobu Nakamura, Yu-Jung Liu, Hiroyuki Nakashima, Hiroki Umehara, Kimiko Inoue, Shogo Matoba,

Makoto Tachibana, Atsuo Ogura, Yoichi Shinkai & Toru Nakano

Nature. 2012 Jun 3;486(7403):415-9

担当：神尾

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

On zygotic development, 5hmC accumulates in the paternal pronucleus along with a

reduction of 5mC.

 knockdown of Tet3 affects the patterns of 5hmC and 5mC in the paternal pronucleus.

 PGC7 protects the maternal genome against 5mC-hydroxylation

PGC7/Stella protects against DNA demethylation in early embryogenesis

PGC7/Stella protects the DNA methylation state of imprinted loci such as H19 and Rasgrf1 and maintains epigenetic asymmetry

担当：高橋