2012年6月14日
Reviews on PR-Set7
PR-Set7/Set8/KMT5a is the sole histone methyltransferase responsible for the monomethylation of histone H4 lysine 20 (H4K20me1)
in higher eukaryotes. Both PR-Set7 and H4K20me1 were previously found to be tightly cell cycle regulated suggesting that they play
an important, although unknown, role in cell cycle progression.
A new regulator of the cell cycle The PR-Set7histone methyltransferase
Cell Cycle 10:1, 68-72 (2011)
This review summarizes the recent reports reveal that PR-Set7 abundance is dynamically regulated during different cell cycle phases by distinct
enzymes including cdk1/cyclinB, Cdc14, SCFSkp2, CRL4cdt2 and APCcdh1. And also it raises some important questions that require further investigation
and explore several possibilities of how PR-Set7 and methylated H4K20 may likely function as novel regulators of the cell cycle.
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription
GENES & DEVELOPMENT 26:325-337 (2012)
This review discusses the substrates and regulation of PR-Set7 first, followed by its role in proper cell cycle progression, the DNA damage response,
gene regulation, and higher-order chromatin structure.
担当：山本(竜)