2012年5月17日

Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA

Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA

Yongxin Yu, Chunying Song, Qiongyi Zhang, Peter A. DiMaggio, Benjamin A. Garcia, Autumn York,
Michael F. Carey, and Michael Grunstein

Key findings of this paper are as follows.
 -H3K56 monomethylation exists in mammalian cells
 -G9a/KMT1C is required for H3K56me1 both in vivo and in vitro
 -Disruption of G9a or H3K56 impairs DNA replication
 -H3K56me1 associates with the replication processivity factor PCNA primarily in G1 phase of the cell cycle and, directly, in vitro
 -H3K56me1 is a chromatin docking site for PCNA prior to its function in DNA replication.

担当:合田