2011年11月17日
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Outline
• By RNA interference and high throughput screening, they identified
the protein bromodomain-containing 4 (BRD4) as being critically
required for disease maintenance in AML.
• Suppression of Brd4 using shRNAs or JQ1, the small-molecule
inhibitor of BET bromodomains, led to robust antileukaemic effects
in vitro and in vivo, accompanied by terminal myeloid
differentiation and elimination of leukemia stem cells.
(担当:遠山)