2011年10月13日
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B
PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B
Atsushi Baba et al. Nature cell biology 13:668-675 June 2011
1) PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an
active H3K9Me2 demethylase through PKA-mediated phosphorylation.
2) Phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and
induce demethylation of methylated ARID5B.
3) Phosphorylated PHF2 and demethylated ARID5B complex removes the
repressive H3K9Me2 mark.
(担当:山崎)