2011年10月13日

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

Atsushi Baba et al. Nature cell biology 13:668-675 June 2011

1) PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an
active H3K9Me2 demethylase through PKA-mediated phosphorylation.

2) Phosphorylated PHF2 then associates with ARID5B, a DNA-binding protein, and
induce demethylation of methylated ARID5B.

3) Phosphorylated PHF2 and demethylated ARID5B complex removes the
repressive H3K9Me2 mark.

(担当:山崎)