2011年7月20日

CTCF-mediated functional chromatin interactome in pluripotent cells

CTCF-mediated functional chromatin interactome in pluripotent cells

Lusy Handoko et al.

Nat Genet. 2011 Jun 19;43(7):630-8. doi: 10.1038/ng.857.

About CCTC-binding factor (CTCF)

・Insulator-binding protein (boundaries between euchromatin and heterochromatin)

・CTCF-mediated interaction and its function have been studied in several selected regions, especially H19-Igf2 locus.

・One of the leading candidates as a global genome organizer

Key findings

・CTCF functions in promoter-enhancer interaction that is different from the previously proposed enhancer blocking model.

・CTCF loops which contain Lamin B-associated domains may act as insulators by establishing boundary structures.

担当：岡部