2011年5月26日

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis
Cell 145, 607-621, May 13, 2011

Highlights
・Class IIa HDACs play an essential role in activating FOXO via deacetylation
・The fasting hormone glucagon induces class IIa HDAC nuclear translocation in liver
・Class IIa HDACs are inhibited by insulin and metformin-dependent activation of AMPK
・Class IIa HDACs play a critical role in glucose homeostasis and metabolic disease

(担当: Tsurutani)