2009年5月12日

H2AXとがん、血管新生、クロモゾーム修復

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.  
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C. 
Cell. 2009 Feb 6;136(3):435-46.

 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. 
Xiao A et al.  
Nature. 2009 Jan 1;457(7225):57-62.

GammaH2AX and cancer.  
Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y. 
Nat Rev Cancer. 2008 Dec;8(12):957-67.

Heterogeneous nuclear ribonucleoprotein L (HnRNP-L) is a subunit of human KMT3a/Set2 complex required for H3 lys36 trimethylation activity in vivo.
Yuan W, Xie J, Long C, Erdjument-Bromage H, Ding X, Zheng Y, Tempst P, Chen S, Zhu B, Reinberg D.
J Biol Chem. 2009 Mar 30. [Epub ahead of print]

Histone H2AX is integral to hypoxia-driven neovascularization.
Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.
Nat Med. 2009 May;15(5):553-8. Epub 2009 Apr 19.