2008年10月31日

EZH2　（第3回）

＜文献＞

H3K27me3によるgene silencingとして、
Gene silencing in cancer by histone H3 lysine 27
trimethylation independent of promoter DNA
methylation. Kondo Y et al. Nat Genet 2008

Regulationのmechanismに関連して、
Substrate Preferences of the EZH2 Histone Methyltransferase
Complex. Martin C, et al. JBC 2006

The Polycomb Repressive Complex 2 Is a Potential Target
of SUMO Modifications. Riising EM, et al. Plos One 2008

Akt-Mediated Phosphorylation of　EZH2 Suppresses Methylation of
Lysine 27 in Histone H3. Cha et al. Science 2005